Molecule Design & Lead Identification
We offer sophisticated design services for mRNA, DNA, and proteins to ensure molecules are optimized for expression, stability, and manufacturability.Guiding you through early pre-clinical research stages leading to DC nomination/ lead molecule identification.
mRNA Drug Substance
Design
- Enhance mRNA stability (half-life), nuclear export, drive superior expression kinetics, and tissue- or cell-type-specific performance - tailored to your therapeutic indication.
- Bespoke guidance on sequence architecture, including codon optimization, secondary structure engineering to fine-tune ribosome loading, choice of cap, polyA tail design, and UTR engineering.
- Guidance on modified nucleotide strategies (e.g., N1-methylpseudouridine) to maximize in vivo stability and reduce innate immune response.
DNA Plasmid Engineering
- Backbone selection for high-copy yield
Strategic plasmid backbone design engineered for maximum DNA yield, with copy number compatibility optimized to your downstream manufacturing scale.
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- Promoter optimization for mRNA & protein expression
Expert selection of promoter systems - including T7 and SP6 for mRNA applications - with nuanced guidance on balancing promoter strength against tight regulatory control for protein expression.
- Linearization strategy design
Tailored linearization approaches that align with your specific application - whether for mRNA synthesis templates or other downstream processing requirements.
- E. coli strain selection for DNA & protein manufacturing
Informed strain selection matched to your production goal — DNA amplification or recombinant protein expression — with guidance on the optimal host characteristics for each use case.
- Antibiotic-free selection systems for clinical compliance
Implementation of antibiotic-free selection strategies to meet clinical and regulatory requirements — enabling cleaner, safer biomanufacturing pipelines ready for GMP-aligned workflows.
Protein design
- Structure-based protein optimization
Deep computational expertise to improve expression, stability, and enzyme catalysis — tuning Km, Kcat, activity, and substrate specificity to your exact goals.
- State-of-the-art molecular dynamics simulations
Structure-guided MD simulations recreate the target biological environment to optimize binding affinity and accurately predict mutant outcomes — maximizing lab success rates.
- Intelligent mutant library design
Rational reduction of library size through predictive modeling — ensuring every variant screened carries a meaningful probability of success and reduces experimental burden.
- Natural variant mining & codon optimization
Systematic identification of naturally occurring variants combined with smart codon selection tailored to the target expression host for maximum yield and reliability.
Let us help maximize your impact.
Smart molecule design is critical for execution!
Our strategy is built for robustness, success and speed. The correct design strategy saves time and decreases wet lab experiment design space, enables faster synthesis and scale up optimization to accelerate development freeing up your resources. Reduction of royalty and licensing costs and avoid common pitfalls. Reduced COGs and longer-term strategy baked in to ensure compliance with regulatory requirements.
Molecule Design FAQs
What types of molecules do you support?
We specialize in mRNA sequence architecture, DNA plasmids, and complex protein designs, including bespoke enzyme engineering for expression, stability and catalysis.
How do you optimize mRNA expression?
Our comprehensive strategy involves codon optimization, secondary structure engineering to fine-tune ribosome loading, specialized UTR and polyA tail engineering tailored to host expression. All designs inherently bake in reduction of innate immune response, manufacturability considerations and cost reduction.
Can you help with insoluble protein expression?
Yes, we solve expression bottlenecks like inclusion bodies and toxic protein expression through tight promoter management, codon variant analysis, scanning and removal of sensitive surface residues and specialized host strain selection.